Publications

Original Article（After 2018）

2024

  1. Amifuji, M.; Inagaki, M.; Yoshida, M.; Doi, T.; Tachikawa, M. Characteristics of membrane transport, metabolism, and target protein binding of cyclic depsipeptide destruxin E in HeLa cells. Drug Metab. Pharmacok. 2024, 58, 101028 (9 pages).
  2. Shirai, T.; Kinoshita, K.; Kumihashi, K.; Mugita, N.; Yoshida, M.; Kigoshi, H. Skin- and airway-deliverable TRPA1 inhibitor. Bioorg. Med. Chem. 2024, 110, 117812 (11 pages).
  3. Sato, H.; Murase, H.; Ishida, Y.; Nakagawa, H.; Yoshida, M.; Doi, T. Destruxin E backbone modification effects on osteoclast Morphology: Synthesis and SAR study of N-Desmethyl and N-Methyl analogs. Bioorg. Med. Chem. 2024, 108, 117777 (12 pages).
  4. Hanada, S.; Yoshida, M.; Kigoshi, H. Concise total synthesis of (-)-berkelic acid via regioselective spiroacetal/pyran formation. Chem. Commun. 2024, 60, 3331-3334.
  5. Ohyoshi, T.; Kigoshi, H. Development of the “Molecular Glue” Using Hybridization of Natural Products. J. Synth. Org. Chem., Jpn. 2024, 82, 483-492.
  6. Hagimoto, K.; Tojo, S.; Teruya, T.; Yoshida, M.; Kigoshi, H. Structure revision of lagunamide C to odoamide by total synthesis and biological evaluation. Tetrahedron 2024, 154, 1333871 (6 pages).

2023

  1. Yoshida, M.; Sasaoka, K.; Hano, K.; Sugiyama, Y.; Hitora, Y.; Doi, T.; Tsukamoto, S.; Kigoshi, H. Synthesis of Biological Evaluation of Siladenoserinol A Analogs Possessing a Diastereomeric 6,8-Dioxabicyclo[3.2.1]octane Skeleton. Bull. Chem. Soc. Jpn. 2023, 96, 1283-1297.
  2. Yoshida, M.; Inaba, T.; Shibuya, Y.; Igarashi, M.; Kigoshi, H. Concise Total Synthesis and Biological Evaluation of Pargamicn A and its Diastereomer, Piperazic Acid-containing Cyclopeptides. ChemPlusChem 2023, 88, e202300339 (6 pages).
  3. Ohyoshi, T.; Iizumi, H.; Hosono, S.; Tano, H.; Kigoshi, H. Total Synthesis of Aplysiasecosterols A and B. Org. Lett. 2023, 25, 4725-4729.
  4. Ohyoshi, T.; Namiki, M.; Miyazaki, Y.; Sato, S.; Noguchi, T.; Kigoshi, H. Toward the Total Synthesis of Scytophycins: Synthesis of the C7-C21 Fragments of Scytophycins A, B, and C. Tetrahedron Lett. 2023, 114, 154250 (5 pages).
  5. Yoshida, M.; Okoshi, Y.; Kigoshi, H. Concise total synthesis and structure revision of metacridamides A and B. Chem. Commun. 2023, 59, 9880-9884.
  6. Takayama, K.; Matsuoka, S.; Adachi, S.; Honma, T.; Yoshida, M.; Doi, T.; Shin-ya, K.; Yoshida, M.; Osada, H.; Inoue, S. Identification of Small-molecule Inhibitors against the Interaction of RNA-binding Protein PSF and its Target RNA for Cancer Treatment. PNAS Nexus 2023, 2, 1-10.

2022

  1. Ohyoshi, T.; Zhao, Y.; Kigoshi, H. Isolation and Synthesis of Azuriaplysins A and B, Bromoditerpenes with an alfa-Methylene Carbonyl From the Sea Hare Aplysia kurodai. J. Nat. Prod., 2022, 8, 2082-2089.
  2. Ohyoshi, T.; Zhao, Y.; Akemoto, K.; Ishihara, T.; Taniguchi, A.; Zhang, M.; Kigoshi, H. Bioinspired Total Synthesis and Structure-Activity Relationship Studies on Aplaminal. Bull. Chem. Soc. Jpn., 2022, 8, 1242-1249.
  3. Mitsugi, K.; Takabayashi, T.; Ohyoshi, T.; Kigoshi, H. Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition-Intramolecular Aldol Reaction. Org. Lett., 2022, 25, 4635-4639.
  4. Yoshida, M.; Nakagawa, H.; Doi, T. Synthetic studies for destruxins and biological evaluation for osteoclast-like multinucleated cells: a review. J. Antibiot. 2022, 75, 420-431.
  5. Yoshida, M.; Matsushita, T.; Kondo, S.; Isoda, H.; Kigoshi, H. Structure Revision of Trichomide D by Total Synthesis. J. Nat. Prod. 2022, 85, 1850-1860.
  6. Ohyoshi, T.; Takano, A.; Kikuchi, I.; Ogura, T.; Namiki, M.; Miyazaki, Y.; Hirano, T.; Konishi, S.; Ebihara, Y.; Takeno, K.; Hayakawa, I.; Kigoshi, H. Structure-Activity Relationship Studies on an Antitumor Marine Macrolide Using Aplyronine A-Swinholide A Hybrid. Org. Biomol. Chem., 2022, 14, 2922-2938.
  7. Yasoshima, K.; Yoshida, M.; Doi, T. The Concise Synthesis of a tert-Butoxycarbonyl Derivative of (3R,4S)-4-Amino-3-hydroxy-7-(N-nitrosohydroxyamino)-2,2-dimethylheptanoate, a Component of JBIR-141. Bull. Chem. Soc. Jpn. 2022, 95, 830-835.

2021

  1. Inaba, T.; Ishizaki, Y.; Igarashi, M.; Yoshida, M.; Kigoshi, H. Total Synthesis of Hytramycin V, an Antibiotic Cyclopeptide. Bull. Chem. Soc. Jpn. 2021, 94, 1922-1930.
  2. Ohyoshi, T.; Tano, H.; Kigoshi, H. Synthetic Studies Toward Aplysiasecosterol a: Concise Synthesis of the Tricyclic Core and Its Reactions for Introduction of the D Ring Fragment. Bull. Chem. Soc. Jpn., 2021, 4, 1179-1184.
  3. Ohyoshi, T.; Kigoshi, H. Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-Depolymerizing Natural Product. Chem. Lett. 2021, 50, 580-584.

2020

  1. Ohyoshi, T.; Mitsugi, K.; Ichimura, F.; Higuma, T.; Yoshida M, Kigoshi H. Total Synthesis and Structure-Activity Relationship Studies of Phelligridins C and D, and Phellifuropyranone A. Bull. Chem. Soc. Jpn. 2020, 93, 1540-1551.
  2. Yoshida, M.; Saito, M.; Ito, S.; Ogawa, K, Goshima N, Nagata K, Doi T. Structure-Activity Relationship Study on Col-003, a Protein-Protein Interaction Inhibitor between Collagen and Hsp47. Chem. Pharm. Bull. 2020, 68, 220-226.
  3. Onda Y, Fukushi K, Ohsawa K, Yoshida M, Masuda Y, Doi T. Synthesis of A Biphenylalanine Analogue of Apratoxin A Displaying Substantially Enhanced Cytotoxicity. Heterocycles 2020, 101, 679-691.

2019

  1. Ito, S.; Saito, M.; Yoshida, M.; Takeuchi, K.; Doi, T.; Nagata, K. A BRET-based Assay Reveals Collagen-Hsp47 Interaction Dynamics in the Endoplasmic Reticulum and Small-Molecule Inhibition of This Interaction. J. Biol. Chem. 2019, 294, 15962-15972.
  2. Ohsawa, K.; Sugai, M.; Zhang, L.; Masuda, Y.; Yoshida, M.; Doi T. Total Synthesis and Structural Revision of Cyclotetrapeptide Asperterrestide A. J. Org. Chem. 2019, 84, 6765-6779.
  3. Ohyoshi, T.; Akemoto, K.; Taniguchi, A.; Ishihara, T.; Kigoshi, H. Total Synthesis of (-)-Aplaminal by Buchwald-Hartwig Cross-Coupling of an Aminal. New J. Chem., 2019, 47, 18442-18444.
  4. Ohyoshi, T.; Mitsugi, K.; Higuma, T.; Ichimura, F.; Yoshida, M.; Kigoshi, H. Concise Total Synthesis of Phelligridins A, C, and D. RSC Advances 2019, 9, 7321-7323.
  5. Yoshida, M.; Adachi, K.; Murase, H.; Nakagawa, H.; Doi T. Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the a-Hydroxycarboxylic Acid Moiety. Eur. J. Org. Chem. 2019, 1669-1676.
  6. Yoshida, M. Combinatorial Synthesis and Biological Evaluation of Destruxins. Chem. Pharm. Bull. 2019, 67, 1023-1029.

2018

  1. Ohsawa, K.; Yoshida, M.; Izumikawa, M.; Takagi, M.; Shin-ya, K.; Goshima, N.; Hirokawa, T.; Natsume, T.; Doi, T. Synthesis and Biological Evaluation of Thielocin B1 Analogues as Protein-Protein Interaction Inhibitors of PAC3 Homodimer. Bioorg. Med. Chem. 2018, 26, 6023-6034.
  2. Yoshida, M.; Saito, K.; Kato, H.; Tsukamoto, S.; Doi, T. Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues. Angew. Chem. Int. Ed. 2018, 57, 5137-5140.
  3. Doi, T.; Masuda, Y.; Yoshida M. 
Cyclodepsipeptide Natural Products Apratoxins A and C and Their Analogs. J. Synth. Org. Chem., Jpn. 2018, 76, 1170-1175.
  4. Yoshida M. Solid-Phase Total Synthesis of Biologically Active Cyclodepsipeptide Spiruchostatin A. J. Synth. Org. Chem., Jpn. 2018, 76, 522-525.

Oral Presentation（After 2024）

2024

  1. 86th Kanto Branch Symposium, The Society of Synthetic Organic Chemistry, Japan. 2024.05.18.　Noda Campus, Tokyo University of Science.
    ◯Mayu Namiki, Shusei Sato, Imari Kikuchi, Takayuki Ohyoshi, and Hideo Kigoshi. Structure-Activity Relationship Study of Scytophycins.
    ◯Keisuke Suzuki, Hideo Kigoshi, and Masahito Yoshida. Total Synthesis of Cyclic Depsipeptide Benderamide A.
    ◯Daiki Shirai, Shione Kojima, Hideo Kigoshi, and Masahito Yoshida. Synthesis and Structure Determination of Destruxin F.
  2. The 104th CSJ Annual Meeting (2024)　2024.03.19~22.　Funabashi Campus, Nihon University
    ◯Hidetada Iizumi, Toru Takabayashi, Takayuki Ohyoshi, and Hideo KIgoshi Synthetic study of hyperuralone A, with a polycyclic carbon skeleton.
    ◯Madoka Suzuki, Masahito Yoshida, and Hideo Kigoshi Synthetic study of Aplyronine A toward Clarification of the Mechanism of Action.
    ◯Takahiro Hirano, Takayuki Ohyoshi, and Hideo Kigoshi Structure-activity relationship study of Aplyronine A using simplified hybrids.
    ◯Mayu Namiki, Shusei Sato, Takayuki Ohyoshi, and Hideo Kigoshi Synthesis and Biological Activity of the Macrolactone Moiety of Scytophycin B.
    ◯Keisuke Nabata, Masahito Yoshida, and Hideo Kigoshi Synthetic Study on Lydiamycins, Cyclic Depsipeptides Containing Piperazic Acid.
    ◯Taishi Okamoto, Masahito Yoshida, and Hideo Kigoshi Synthetic Study of Alotamide A, a Cyclodepsipeptide.
    ◯Kazuki Hagimoto, Toshiaki Teruya, Masahito Yoshida, and Hideo Kigoshi Synthesis and Structure Revision of a Marine Cyanobacteria-Derived Natural Product Lagunamide C.
  3. The 65th Symposium on the Chemistry of Natural Products　2023.09.13~15.　Hongo Campus, The University of Tokyo.
    ◯Takyuki Ohyoshi, Hidetada Iizumi, Shu Hosono, Hikaru Tano, and Hideo Kigoshi Total Synthesis of Aplysiasecosterols A and B, Two Marine 9,11-Secosteroids.
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